Eludril Clinical Study 2

Authors: C Hermant, J Luc, C Roques, F Petureau, R Escamilla, M Federlin-Ducani

Publication: Med Mal Infect 1997; 27 715-8.

Title: In vitro fungicidal activity of main antiseptic solutions used as mouthwash against gingival fungal strains in HIV infected patients

Summary:

Oral candidiasis, including severe gingivo-periodontal disorders, is commonly observed in HIV infected patients.  This leads to a wide administration of general antifungal treatment.  Moreover, the emergence of azole-resistant strains has been recently demonstrated.  A study was performed to assess the fungicidal activity of the main antiseptic solutions used as mouthwash.  Gingival samples were obtained from 76 HIV infected patients and studied.  Cultures were positive in 46 cases; Candida albicans was the most common yeast encountered (82.6%).  In the assessed mouthwash solutions, cetylpyridinium chloride demonstrated no efficiency and solutions containing hexetidine or thyrotricine showed a weak fungicidal activity.  Solutions containing Chlorhexidine showed similar efficiency up to 1/16 dilution.  Solutions containing 0.10% chlorhexidine exhibited equal antifungal activity compared to more concentrated solutions.  Mouthwash containing chlorhexidine might be of interest as supplement treatment of oral candidiasis in HIV infected patients.  Furthermore, in such patients, prophylactic treatment might delay the administration of general antifungal drugs and limit the emergence of resistant strains to azoles.