Eludril Clinical Study 3

Authors: J Luc, C Mroz, C Roques, M Ducani-Federlin

Publication: Journal de parodontologie & d’implantologie orale, Vol 17, No. 4/98, pp 441-446

Title: Bactercidal activity of mouthrinses containing 0.10%, 0.12% or 0.20% chlorhexidine digluconate

Abstract:

The antiseptic activity of five mouthrinses containing 0.10%, 0.12% or 0.20% chlorhexidine digluconate and of three aqueous solutions of chlorhexidine in the same concentrations was determined.  French Pharmacopoeia (1997) recommendations were followed with respect to both evaluation methods and test conditions (dilutions recommended by the manufacturers and brief contact time).  Results showed that the three aqueous solutions and the two 0.12% chlorhexidine digluconate preparations had no antiseptic activity (logarithmic reduction <5).

Bactericidal activity of various dilutions of these same products on nine pathogenic bacterial species was tested using an appropriate micromethod.  Bactericidal activity of the mouthrinses varied widely and was not correlated with that of the matching aqueous chlorhexidine solutions: the 0.10% mouthrinse was as active as the 0.20% aqueous solution, and overall the 0.12% mouthrinses were less active than the 0.12% aqueous solutions.  These data indicate that the chlorhexidine concentration in mouthrinses fails to predict antibacterial efficacy and that excipients play a key role in modulating the efficacy of chlorhexidine.